Robert Zemeckis' 1988 film combines animation with live-action film to tell the story of Eddie Valiant, a detective who lives in a world where humans and cartoons live side-by-side in Hollywood. Eddie wants nothing to do with "toons" after the mysterious death of his brother, in which he believes a toon was involved, but he's soon asked to investigate a case involving Roger Rabbit, a cartoon comedy star who swears his innocence.
Actress Nancy Cartwright, who voices Bart Simpson on the long-running animated sitcom "The Simpsons," voiced a cartoon shoe which is dipped in chemicals in the film.
Animated characters from multiple studios appear in the film 鈥 for example, Donald Duck of Disney and Daffy Duck of Warner Bros. play the piano together onstage at one point in the movie.