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With one off-key comment by the Republican nominee, the Missouri Senate race has taken a dramatic turn 鈥� and suddenly, Democrats are thinking they might be able to save their most vulnerable Senate seat.

Rep. Todd Akin (R) told a TV interviewer Sunday that women鈥檚 bodies are almost always able to prevent pregnancy in cases of 鈥渓egitimate rape.鈥� The six-term congressman, who faces first-term Sen. Claire McCaskill (D) in November, was responding to a question on a St. Louis television station about abortion.

Pregnancies from rape are 鈥渞eally rare,鈥� Congressman Akin said, basing this view on 鈥渨hat I understand from doctors.鈥� He opposes abortion in all instances, including for pregnancies that result from rape.

鈥淚f it鈥檚 a legitimate rape, the female body has ways to try to shut that whole thing down,鈥� Akin said on KTVI-TV. 鈥淏ut let鈥檚 assume that maybe that didn鈥檛 work or something: I think there should be some punishment, but the punishment ought to be of the rapist, and not attacking the child."

After immediate expressions of outrage from women鈥檚 groups and Democrats 鈥� including Senator McCaskill, who blasted Akin on Twitter 鈥� the congressman said he 鈥渕isspoke.鈥�

鈥淚n reviewing my off-the-cuff remarks, it鈥檚 clear that I misspoke in this interview, and it does not reflect the deep empathy I hold for the thousands of women who are raped and abused every year,鈥� Akin said in a statement. 鈥淚 recognize that abortion, and particularly in the case of rape, is a very emotionally charged issue. But I believe deeply in the protection of all life, and I do not believe that harming another innocent victim is the right course of action.鈥�

Sunday night, the Romney campaign said Mitt Romney and his running mate, Paul Ryan, disagree with Akin and that a Romney-Ryan administration would not oppose abortion in cases of rape.

Conservative commentators 鈥� including Reihan Salam of National Review and John McCormack of The Weekly Standard 鈥� called on Akin to drop out of the race.

One point is clear: The Missouri Senate race has a new complexion, as general election voters take a closer look at the conservative House member who won his party鈥檚 nomination on Aug. 7 with just 36 percent of the vote in a crowded field. McCaskill, a Democrat in an increasingly Republican state, became especially vulnerable when it came out last year that taxpayer money was used to fund her senatorial use of a private plane she co-owns with her husband and friends.

Before his comment, Akin was beating McCaskill by an average five percentage points, according to Real Clear Politics.

The Democrats currently control the Senate by a slim 53-to-47 margin, in a cycle with many more opportunities for Republicans to win seats than for Democrats. But Democrats aren鈥檛 stopping with blasting the Akin comment to save McCaskill 鈥� they鈥檙e trying to make Akin the third member of the Romney-Ryan ticket.

鈥淣ow, Akin's choice of words isn't the real issue here,鈥� Democratic National Committee chairwoman Debbie Wasserman Schultz wrote in an e-mail to supporters overnight. 鈥淭he real issue is a Republican Party 鈥� led by Mitt Romney and Paul Ryan 鈥� whose policies on women and their health are dangerously wrong.鈥�

The episode plays right into the Democrats鈥� hands. For months, they have been saying the Republicans are waging a 鈥渨ar on women鈥� with their policies on contraception, abortion, health insurance, and women鈥檚 pay. President Obama has long enjoyed a gender gap with voters, and hopes to run up his numbers as much as possible with women to make up for his deficit among men.聽